The majority of shows I have done with sequences and clicks sounded great as long as the drummer could hear well. We would tour with a sidefill monitor that the drummer could control his own eq and volume on. This made things go real smooth. Most of the time, the sequences were in and out for me. I just learned to follow the songs based on the drums and a guitarist and that made things comfortable.
The only thing that made things shakey was samples that were recorded at a low volume. So basically, if you have a strong drummer with a good monitor and you make sure the sequences are consistent the show should be fine.
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