A non-true (false?) bypass pedal can change your guitar's output impedance even when switched off. It would sound as if it weren't even inline if true bypass. In a chain of pedals it will probably distort the signal going into the next pedal and add noise. You can put it at the end of the chain, but sometimes that just isn't as fun. My old Ibanez Soundtank delay pedal is notorious for noise. Really cool combined with another delay pedal... but it goes SHHHHHHHHHHHHH...
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