I'd go for a Mac in terms of Audio or reliability. I've hardly ever had to deal with programs not working for no reason or deal with setup issues. Pretty much what gets opened or plugged into a Mac works. Searching for samples, slogging through program windows is a lot easier on a Mac because of Expose and some other Mac-OS based features. Plus it has Plogue's Bidule and TimeWarp and Musolomo's stuff which is Mac only. A lot of the eye candy stuff isn't super-taxing on the computer either. I own an XP machine and a Mac, the Mac is the cpu I use 95% of the time now.
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